- Stock #1180-3 (60 capsules)
Nature’s Phenyltol contains a unique blend of nutrients and herbs that have been shown to help relieve joint pain and inflammation without causing gastrointestinal irritation or other side-effects commonly associated with over-the-counter and prescription pain-relievers. Nature’s Phenyltol also provides the added benefit of NEM (natural eggshell membrane), which contains naturally-occurring substances needed for healthy joint function and connective tissue production. Nature’s Phenyltol may be beneficial for those with osteo- or rheumatoid arthritis, back pain, headaches, rheumatic complains, or even nerve-related pain such as sciatica. Each capsule of Nature’s Phenyltol contains:
1-10(DLPA) is a combination of the essential amino acid L-phenylalanine (found in animal protein) and D-phenylalanine (found in plant and bacterial cultures). L-phenylalanine is a precursor to l-tyrosine, an amino acid necessary for the production of the mood-regulating neurotransmitters, norepinephrine, epinephrine (also known as adrenaline) and dopamine. D-phenylalanine inhibits the action of enzymes that break down endorphins and enkephalins—morphine-like hormones that act as natural pain-killers to reduce the sensation of pain. Individuals suffering from chronic pain exhibit decreased levels of endorphin activity. Thus, preliminary studies suggest that DLPA may help relieve pain and provide antidepressant effects in individuals suffering from osteoarthritis, rheumatoid arthritis, low back pain and migraine headaches.
Although most studies indicate an absence of side effects or contraindications, with the exception of an increase in blood pressure in a few individuals, DL-phenylalanine should be avoided by those with phenylketonuria (PKU), a genetic defect in the body’s ability to metabolize phenylalanine. DL-phenylalanine is not recommended during pregnancy and should not be taken in conjunction with antidepressant medications (particularly MAO inhibitors). Individuals with hypertension or schizophrenia should consult their health care professional before taking DL-phenylalanine.2,3,10
1,11-20(Natural Eggshell Membrane) – The eggshell membrane, which separates the egg from the calcified shell, is composed of protein fibers and other nutrients, including collagen, glucosamine, chondroitin and hyaluronic acid. These nutrients naturally occur in the human body, where they function as key components of connective tissues such as cartilage. For example, collagen is responsible for maintaining the integrity of tendons, ligaments and cartilage; glucosamine stimulates the production of substances needed for cartilage development and regeneration; chondroitin is a major component of joint cartilage, responsible for drawing and maintaining fluids within the cartilage; and hyaluronic acid is a ubiquitous (existing everywhere) component of connective tissue that also plays an important role in maintaining synovial fluid to lubricate the joints. Thus, use of eggshell membrane as a natural source of these important nutrients may facilitate joint health and function.
21-29contains the active ingredient salicin, which is metabolized in the body into salicylic acid—a chemical relative of acetylsalicylic acid and the active ingredient in aspirin. Salicylic acid helps relieve inflammation and pain by inhibiting COX-2 activity. COX-2 (cyclooxygenase-2) is an enzyme that stimulates the release of hormone-like compounds called prostaglandins, which cause inflammation and pain. Thus, willow bark is predominantly used as a natural anti-inflammatory for symptomatic relief of gouty arthritis and as an analgesic (pain-reliever) for mild neuralgic pains (nerve-related pain), toothaches and headaches. The German Commission E has approved willow bark for rheumatic ailments, headaches, and diseases accompanied by fever. A number of clinical studies have proven the efficacy of willow bark extract in painful inflammatory and degenerative rheumatic diseases, while randomized, double-blind studies have found standardized willow bark extract to be far more effective than placebo for treating chronic low back pain and osteoarthritis. In addition, a randomized, controlled clinical trial comparing the effects of willow bark extract to the prescription drug rofecoxib (a synthetic COX-2-inhibitor) found no significant difference in effectiveness between the two treatments, other than willow bark was about 40% less expensive than the drug.
It is important to note that willow bark does not interfere with coagulation—it does not prolong bleeding time, nor does it inhibit platelet aggregation. In addition, willow bark’s active ingredients are metabolized by the liver, by-passing the gastrointestinal tract and thus, avoiding gastrointestinal irritation.21,23
30-37has been used for centuries in Traditional Chinese Medicine to relieve inflammation, rheumatoid arthritis, and low back and leg pain. In Japanese herbal medicine, known as Kampo, morinda root is given for pain and weakness in the lower back, as well as joint pain, torn ligaments, broken or degenerating bones, and even menstrual pain. Morinda root is also taken for general pain that seems to migrate throughout the body. An extract of morinda root has been shown to inhibit the production of nitric oxide, as well as block COX-2 activity. In addition, researchers have identified several compounds in morinda root that possess antidepressant activity.
30,38-50has been used throughout history, dating back to ancient Egypt, for its sedative effects on the nervous system. Wood betony acts as a relaxant and tonic for the nervous system, helping to calm nervous tension and soothe pain, especially nerve pain. Wood betony has been indicated for a variety of health problems, including arthritic conditions, gout, hypertension, menstrual pain, migraines, neuralgia, nervous disorders, rheumatism, sciatica, and headaches stemming for poor circulation and nervous tension. Although few scientific studies have been published in peer-reviewed medical journals, Russian researchers have identified substances in wood betony that possess anti-inflammatory and hypotensive (blood pressure-lowering) actions. For example, wood betony contains the iridoid glycoside, harpagide, which demonstrates analgesic, antiarthritic and anti-inflammatory properties.
1Lininger DC, S., et al. The Natural Pharmacy. Rocklin, CA: Prima Health, 1998.
2Chaitow, L. Thorsons Guide To Amino Acids. London, England: Thorsons, 1991.
3“DL-Phenylalanine.“ PDRhealth. . Accessed August 2006.
4Kitade, T., et. al. “Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (first report)—effect on pain threshold and inhibition by naloxone.“ Acupuncture and Electrotherapy Research; 1988, 13(2-3): 87-97.
5Walsh, N.E., et. al. “Analgesic effectiveness of D-phenylalanine in chronic pain patients.“ Archives of Physical Medicine and Rehabilitation; 1986, 67(7):436-439.
6Donzelle, G., et. al. “Curing trial of complicated oncologic pain by D-phenylalanine.“ Anesthesia and Analgesia; 1981, 38(11-12): 655-658.
7Saltmarsh, N. “Remedy headaches with natural pain relievers.“ Better Nutrition, July, 1989. . Accessed June 2006.
8Almay, B.G., et. al. “Endorphins in chronic pain. I. Differences in CSF endorphin levels between organic and psychogenic pain syndromes.“ Pain; 1978, 5(2):153-162.
9Laorden, M.L., et. al. [Measurement of endorphins in human cerebrospinal fluid. Comparative study of various groups of patients]. Revista Española de Fisiologia; 1982, 38(3):277-284.
10Mindell PhD, E. & Hopkins, V. Prescription Alternatives. New Canaan, CT: Keats Publishing, 1998.
11Arias, J.L., et. al. “The fabrication and collagenous substructure of the eggshell membrane in the isthmus of the hen oviduct.“ Matrix; 1991, 11(5):313-320.
12Long, F.D., et. al. “Preparation of hyaluronic acid from eggshell membrane.“ United States Patent 6946551. Free Patents Online; 2005. . Accessed September 2006.
13Heaney, R.K. & Robinson, D.S. “The isolation and characterisation of hyaluronic acid in egg shell.“ Biochimica et Biophysica Acta; 1976, 451(1):133-142.
14Wong, M., et. al. “Collagen in the egg shell membranes of the hen.“ Developmental Biology; 1984, 104(1):28-36.
15Robel, E.J. “Levels of calcium and soluble collagen in turkey egg shell membranes.“ Comparative Biochemistry and Physiology. A, Comparative Physiology; 1988, 90(3):421-424.
16Pizzorno, J & Murray, M (eds). A Textbook of Natural Medicine, 2nd Ed. London: Churchill Livingstone, 1999.
17May, M., et. al. “The role of glucosamine, chondroitin and thymoquinone on the viability and proliferation of a HTB-93 rheumatoid arthritis cell model.“ Biomedical Sciences Instrumentation; 2006, 42:338-343.
18Cooper RPh, C. “Chronic Joint Pain.” Nutrition Science News; January, 1999.
19Galus, R., et. al. [Clinical applications of hyaluronic acid]. Polski Merkuriusz Lekarski; 2006, 20(119):606-608.
20“Chondroitin Sulfate.“ PDRhealth. . Accessed September 2006.
21Presser PharmD, A. Pharmacist’s Guide to Medicinal Herbs. Petaluma, CA: Smart Publications, 2000.
22White MD, L. “Pain-free joints, naturally.” Herbs For Health; 2001, 6(3):38-42.
23“Willow Bark: The Aspirin Raw Material.” Nutrition Science News; June, 2001.
24Khalsa, K. “Treating carpal tunnel syndrome.” Herbs For Health; 2001, 6(4):10-12.
25Herbal Medicine: Expanded Commission E Monographs. Integrative Medicine Communications, 2000.
26Chrubasik, S. & Pollak S. [Pain management with herbal antirheumatic drugs]. Wiener Medizinische Wochenschrift; 2002;152(7-8):198-203.
27Chrubasik, S., et. al. “Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study.” American Journal of Medicine; 2000, 109(1):9-14.
28Schmid, B., et. al. “Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial.” Phytotherapy Research; 2001, 15(4):344-350.
29Chrubasik, S., et. al. “Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain.” Rheumatology (Oxford); 2001, 40(12):1388-1139.
30Chevallier, A. The Encyclopedia of Medicinal Plants. NY, NY: DK Publishing, 1996.
31Tierra LAc, M. The Way of Chinese Herbs. NY, NY: Pocket Books, 1998.
32Lu, H. Chinese Herbal Cures. NY, NY: Sterling Publishing Co., 1994.
33Bensky, D. & Gamble, A. Chinese Herbal Medicine Materia Medica, Revised Ed. Seattle, WA: Eastland, 2003.
34Choi J, et. al. “Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis.“ Biological & Pharmaceutical Bulletin; 2005, 28(10):1915-1918.
35Rister, R. Japanese Herbal Medicine. Garden City Park, NY: Avery Publishing, 1999.
36Kim, I.T., et. al. “In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis.“ The Journal of Pharmacy and Pharmacology; 2005, 57(5):607-615.
37Cui, C., et. al. [Antidepressant active constituents in the roots of Morinda officinalis How]. Zhongguo Zhong Yao Za Zhi; 1995, 20(1):36-39, 62-63.
38Mowrey, D. The Scientific Validation of Herbal Medicine. New Canaan, CT: Keats Publ., 1986.
39—. “Valerian root, passion flower, and ginkgo are top \’neurotonic\’ herbs.“ Better Nutrition; January 1997. . Accessed July 2006.
40PDR for Herbal Medicines, 2nd Ed. Montvale, NJ: Medical Economics Company, 2000.
41Gormley, J.J. “White willow bark is a gentle, effective pain-reliever.“ Better Nutrition; March 1996. . Accessed September 2006.
42Bown, D. Encyclopedia of Herbs & Their Uses. NY, NY: Dorling Kindersley Inc., 1995.
43Miller, L. & Murray, W. Herbal Medicinals. Binghampton, NY: Pharmaceutical Products Press, 1998.
44Ody, P. The Complete Medicinal Herbal. NY, NY: Dorling Kindersley Inc., 1993.
45Rowland, B. “Migraine headache.“ Encyclopedia of Alternative Medicine; 2001. . Access July 2006.
46Peirce, A. Practical Guide to Natural Medicines. NY, NY: The Stonesong Press, Inc., 1999.
47McIntyre, A. Flower Power. NY, NY: Henry Holt and Co., 1996.
48Foster, S. & Tyler PhD, V.E. Tyler’s Honest Herbal, 4th Ed. Binghampton, NY: Haworth Herbal Press, 1999.
49Colas, C., et. al. “Proton and sodium cation affinities of harpagide: a computational study.“ Journal of Physical Chemistry A: Molecules, spectroscopy, kinetics, environment & general theory; 2006, 110(23):7503-7508.
50Duke, J.A. “Biological Activities of harpagide.“ Dr. Duke’s Phytochemical and Ethnobotanical Databases. Accessed September 2006.