- Stock #808-3 (90 capsules)
Super ORAC is a powerful antioxidant formula that provides a rich blend of antioxidants and other health-promoting nutrients known to protect the body’s tissues against oxidative stress and illness caused by free radicals—highly reactive molecules that can destroy cellular compounds, including DNA. Free radical damage to cells has been linked to the development of cancer and other debilitating diseases, including atherosclerosis, Alzheimer’s disease, cataracts, osteoarthritis, and immune deficiency. Research shows that antioxidant nutrients can help prevent illness and treat degenerative disorders associated with free radical damage. The unique combination of antioxidant ingredients in Super ORAC, which includes extracts of green tea, mangosteen, turmeric, apple and açai berry, along with quercetin, resveratrol and selenium, provides a high ORAC value. Oxygen radical absorbance capacity (ORAC) is a standard measurement of antioxidant activity used in the nutraceutical, pharmaceutical and food industries. Each capsule of Super ORAC contains:1-5
Camellia sinensis) is a rich source of antioxidant nutrients, including polyphenols (catechins and gallic acid), carotenoids, tocopherols, ascorbic acid (vitamin C), and selenium. ORAC assays have shown that green tea exhibits much higher antioxidant activity against peroxyl radicals than many vegetables. Numerous human studies have demonstrated a significant increase in plasma antioxidant capacity following consumption of moderate amounts of green tea, leading to reduced oxidative damage in macromolecules such as DNA and lipids (fats). Research has also shown that green tea extract functions better against oxidative damage of human red blood cells compared to both black and white tea extracts. The majority of human epidemiological and intervention studies demonstrates beneficial effects of green tea or green tea extracts rich in EGCG (epigallocatechin-3-gallate, the major antioxidant polyphenol in green tea) on weight management, glucose control and cardiovascular risk factors. In addition, a number of studies have shown a significant protective role of green tea against various liver diseases, including cirrhosis, fatty liver disease and liver cancer. Furthermore, the anti-carcinogenic properties of the antioxidants in green tea are supported by numerous epidemiological studies. Over half of the studies reviewed suggest that long-term consumption of green tea may lower the risk of certain types of cancer, especially gastrointestinal cancers such as colorectal, esophageal, liver, pancreatic and stomach cancer. There is also some epidemiological evidence demonstrating protective effects of green tea consumption on breast, lung and prostate cancer.6-12(
Garcinia mangostana) – In recent years, scientists have discovered that mangosteen contains a class of naturally occurring polyphenolic compounds known as xanthones, which demonstrate potent antioxidant, anti-inflammatory, antithrombotic, antitumoral, neuroprotective (protecting against nerve damage), and antibacterial effects. Xanthones and xanthone derivatives have been shown to provide beneficial effects on cardiovascular diseases and to demonstrate anticancer activity. For example, recent research has confirmed that xanthone constituents exhibit dose-dependent aromatase inhibitory activity—inhibiting the aromatase enzyme decreases estrogen production in the body and has proven to have a significant effect on the development and progression of hormone-responsive breast cancer. In addition, mangosteen also contains oligomeric proanthocyanidins, which are potent peroxyl radical scavengers that demonstrate much higher antioxidant activity than either pine bark or grape seed extracts.13-20(
21-29contains antioxidants known as curcuminoids, which demonstrate potent antioxidant, anti-inflammatory and antitumor properties. Curcumin, the primary active curcuminoid, exhibits potent antioxidant activity that is comparable to vitamins A, C and E. Given its direct antioxidant and free radical scavenging effects, curcumin is thought to play a vital role against the oxidative damage to lipids, proteins and DNA associated with chronic illnesses such as atherosclerosis, cancer and neurodegenerative diseases. Curcumin has also been shown to protect the liver, pancreas and nervous system against the toxic effects of alcohol consumption. Furthermore, curcumin exhibits great promise as a therapeutic agent and is currently being researched in human clinical trials for conditions including Alzheimer’s disease, colon cancer, multiple myeloma, pancreatic cancer, and psoriasis. Curcumin has been shown to be non-toxic even at high dosages and has been given the classification of \’generally recognized as safe\’ (GRAS) by the National Cancer Institute.
Sophora japonica) – Quercetin is one of the most prominent dietary antioxidants found in foods, including fruit, vegetables, tea and wine. Quercetin is also found in Sophora japonica, a traditional Chinese herb. Quercetin exhibits strong antioxidant properties and increases glutathione levels and antioxidant enzyme function. Research has shown that quercetin protects cells against oxidative damage to both nuclear and mitochondrial DNA. Evidence also indicates that quercetin may be of therapeutic benefit in the treatment of cancer and cardiovascular disease, as well as age-related health problems resulting from oxygen free radical damage.30-39(
Polygonum cuspidatum) is found in a variety of plants, with the richest source derived from the roots of Japanese knotweed, a traditional Chinese medicine. Resveratrol is produced as part of the plant’s defense mechanism in response to stress conditions. Intensive research has focused on resveratrol due to its antioxidant and anti-inflammatory effects and its emerging potential for cancer prevention and promoting longevity. Resveratrol’s anti-carcinogenic and anti-aging effects appear to be closely associated with its antioxidant activities. In addition, growing evidence has confirmed resveratrol’s cardioprotective effects.40-48(from Japanese Knotweed –
Malus domestica) – Compared to many other commonly consumed fruits in the United States, apples have the second highest level of antioxidant activity. Apples contain a variety of phytochemicals, including quercetin, rutin and catechin, all of which are potent antioxidants capable of protecting cells and tissues from oxidative stress and related DNA damage. For example, research indicates that apples can inhibit cancer cell proliferation, decrease lipid (fat) oxidation, and lower cholesterol. Epidemiological studies have linked apple consumption with reduced risk of some cancers, as well as asthma, cardiovascular disease and diabetes. Plus, apple consumption has been positively associated with increased weight-loss and general pulmonary (lung) health, including increased lung function. Based on these epidemiological studies, it appears that apples may play a large role in reducing the risk of a wide variety of chronic diseases and in maintaining a healthy lifestyle.49-52(
Euterpe oleracea), a fruit from the Amazon region of South America, is a rich source of antioxidants called polyphenols. In some regions of Brazil, açai is used for health problems related to oxidative damage, such as cardiovascular disorders. According to research, açai has demonstrated exceptional antioxidant activity against superoxide radicals, as well as the highest antioxidant capacity of any food currently reported against peroxyl radicals. In addition, plasma antioxidant capacity has been shown to increase up to 2- and 3-fold following the consumption of açai juice and pulp among healthy volunteers. Açai also exhibits anti-inflammatory properties and appears to be a potential inhibitor of COX-1 and COX-2—enzymes involved in the inflammatory response.53-56(
57-64, an essential trace element that must be obtained in the daily diet, is one of the most common nutrient deficiencies. Selenium is best known as an antioxidant and for its ability to reduce oxidative stress and DNA damage. However, selenium also functions as a cancer preventive agent. Selenium supplementation has demonstrated benefit in reducing the risk of cancer incidence and mortality (death), particularly in colorectal, liver, lung and prostate cancers, with the greatest effect among patients with the lowest selenium status. There is also evidence that selenium may alter cancer progression and metastasis. In addition, selenium deficiency appears to be associated with reduced thyroid hormone metabolism and the conversion of T4 to T3; carcinogenesis in various sites throughout the body; liver disease, including cirrhosis and hepatitis; rheumatoid arthritis; adult asthma; male infertility; and, chronic kidney disease. Furthermore, since increased oxidative stress contributes to the development and progression of chronic heart failure, selenium supplementation may prove beneficial by enhancing antioxidant protection.
1Tapiero, H., et. al. “Polyphenols: do they play a role in the prevention of human pathologies?” Biomedicine & Pharmacotherapy; 2002, 56(4):200-207.
2Gazella, K. “Evaluating antioxidant supplements.” Nature’s Impact; April/May 1998, 8-9.
3Murray, M., Pizzorno, J. Encyclopedia of Natural Medicine. Rocklin, CA: Prima Publishing, 1998.
4Devasagayam, T.P., et. al. “Free radicals and antioxidants in human health: current status and future prospects.” The Journal of the Association of Physicians of India; 2004, 52:794-804.
5Huang, D., et. al. “High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format.” Journal of Agricultural and Food Chemistry; 2002, 50(16):4437-4444.
6Cabrera, C., et. al. “Beneficial effects of green tea–a review.“ Journal of the American College of Nutrition; 2006, 25(2):79-99.
7Hakim, I.A., et. al. “Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype.“ Journal of Nutrition; 2008, 138(8):1567S-1571S.
8Gawlik, M., Czajka, A. “The effect of green, black and white tea on the level of alpha and gamma tocopherols in free radical-induced oxidative damage of human red blood cells.“ Acta Poloniae Pharmaceutica; 2007, 64(2):159-164.
9Lee, Y.L., et. al. “An extract of green tea, epigallocatechin-3-gallate, reduces periapical lesions by inhibiting cysteine-rich 61 expression in osteoblasts.“ Journal of Endodontics; 2009, 35(2):206-211.
10Thielecke, F., Boschmann, M. “The potential role of green tea catechins in the prevention of the metabolic syndrome – A review.“ Phytochemistry; 2009, 70(1):11-24.
11Jin, X., et. al. “Green tea consumption and liver disease: a systematic review.“ Liver International; 2008, 28(7):990-996.
12Liu, J., et. al. “Green tea (Camellia sinensis) and cancer prevention: a systematic review of randomized trials and epidemiological studies.“ Chinese Medicine; 2008, 3:12.
13Chen, L.G., et. al. “Anti-inflammatory activity of mangostins from Garcinia mangostana.“ Food and Chemical Toxicology; 2008, 46(2):688-693.
14Weecharangsan, W., et. al. “Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.).” Medical Principles and Practice; 2006, 15(4):281-287.
15Pedraza-Chaverri, J., et. al. “Medicinal properties of mangosteen (Garcinia mangostana).“ Food and Chemical Toxicology; 2008, 46(10):3227-3239.
16Chomnawang, M.T., et. al. “Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus.“ Fitoterapia; 2009, 80(2):102-104.
17Jiang, D.J., et. al. “Pharmacological effects of xanthones as cardiovascular protective agents.” Cardiovascular Drug Reviews; 2004, 22(2):91-102.
18Itoh, T., et. al. “Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.“ Bioorganic & Medicinal Chemistry; 2008, 16(8):4500-4508.
19Balunas, M.J., et. al. “Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.“ Journal of Natural Products; 2008, 71(7):1161-1166.
20Fu, C., et. al. “Oligomeric proanthocyanidins from mangosteen pericarps.“ Journal of Agricultural and Food Chemistry; 2007, 55(19):7689-7694.
21“Curcuma longa (turmeric). Monograph.” Alternative Medicine Review; 2001, 6 Suppl:S62-66.
22Herbal Medicine: Expanded Commission E Monographs. Integrative Medicine Communications, 2000.
23Fetrow PharmD, C. & Avila PharmD, J. Professional’s Handbook of Complementary & Alternative Medicines. Springhouse, PA: Springhouse Corp., 1999.
24Katsuyama, Y., et. al. “Curcuminoid biosynthesis by two type III polyketide synthases in the herb curcuma longa.“ The Journal of Biological Chemistry; 2009, Mar. 3. [Epub ahead of print]
25Menon, V.P., Sudheer, A.R. “Antioxidant and anti-inflammatory properties of curcumin.“ Advances in Experimental Medicine and Biology; 2007, 595:105-125.
26Wongcharoen, W., Phrommintikul, A. “The protective role of curcumin in cardiovascular diseases.“ International Journal of Cardiology; 2009, Feb. 20. [Epub ahead of print]
27Giannessi, F., et. al. “Curcumin protects Leydig cells of mice from damage induced by chronic alcohol administration.“ Medical Science Monitor; 2008, 14(11):BR237-242.
28Hatcher, H., et. al. “Curcumin: from ancient medicine to current clinical trials.“ Cellular and Molecular Life Sciences; 2008, 65(11):1631-1652.
29Itokawa, H., et. al. “Recent advances in the investigation of curcuminoids.“ Chinese Medicine; 2008, 3:11.
30Boots, A.W., et. al. “Health effects of quercetin: from antioxidant to nutraceutical.“ European Journal of Pharmacology; 2008, 585(2-3):325-337.
31Lamson, D.W., Brignall, M.S. “Antioxidants and cancer, part 3: quercetin.“ Alternative Medicine Review; 2000, 5(3):196-208.
32Bok, S.H., et. al. “Quercetin dihydrate and gallate supplements lower plasma and hepatic lipids and change activities of hepatic antioxidant enzymes in high cholesterol-fed rats.“ International Journal for Vitamin and Nutrition Research; 2002, 72(3):161-169.
33Lao, C.J., et. al. “Microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats.“ The American Journal of Chinese Medicine; 2005, 33(3):425-438.
34Ansari, M.A., et. al. “Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer’s disease.“ The Journal of Nutritional Biochemistry; 2009, 20(4):269-275.
35Johnson, M.K., Loo, G. “Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.“ Mutation Research; 2000, 459(3):211-218.
36Potenza, L., et. al. “Effect of quercetin on oxidative nuclear and mitochondrial DNA damage.“ Biofactors; 2008, 33(1):33-48.
37Perez-Vizcaino, F., et. al. “Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols.“ Free Radical Research; 2006, 40(10):1054-1065.
38Janson, M. “Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging.“ Clinical Interventions in Aging; 2006, 1(3):261-265.
39Singh, A., et. al. “Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid.“ Free Radical Research; 2003, 37(11):1245-1252.
40de la Lastra, C.A., Villegas, I. “Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications.“ Biochemal Society Transactions; 2007, 35(Pt 5):1156-1160.
41Vaher, M., Koel, M. “Separation of polyphenolic compounds extracted from plant matrices using capillary electrophoresis.“ Journal of Chromatography. A.; 2003, 990(1-2):225-230.
42Wang, D., et. al. “Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE).“ Phytomedicine; 2008, 15(10):859-866.
43Das, D.K., Maulik, N. “Resveratrol in cardioprotection: a therapeutic promise of alternative medicine.“ Molecular Interventions; 2006, 6(1):36-47.
44Athar, M., et. al. “Resveratrol: a review of preclinical studies for human cancer prevention.“ Toxicology and Applied Pharmacology; 2007, 224(3):274-283.
45Gatz, S.A., Wiesmüller, L. “Take a break—resveratrol in action on DNA.“ Carcinogenesis; 2008, 29(2):321-332.
46Rocha-González, H.I., et. al. “Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases.“ CNS Neuroscience & Therapeutics; 2008, 14(3):234-247.
47Wong, Y.T., et. al. “Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: protection by chronic oral intake of resveratrol.“ Free Radical Biology & Medicine; 2009, 46(6):799-809.
48Das, S., Das, D.K. “Resveratrol: a therapeutic promise for cardiovascular diseases.“ Recent Patents on Cardiovascular Drug Discovery; 2007, 2(2):133-138.
49Lotito, S.B. & Frei, B. “Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects.” Free Radical Biology & Medicine; 2004, 36(2):201-211.
50Boyer, J. & Liu, R.H. “Apple phytochemicals and their health benefits.” Nutrition Journal; 2004, 3(1):5.
51Wolfe KL, et. al. “Cellular antioxidant activity of common fruits.“ Journal of Agricultural and Food Chemistry; 2008, 56(18):8418-8426.
52Maffei, F., et. al. “Relevance of apple consumption for protection against oxidative damage induced by hydrogen peroxide in human lymphocytes.“ The British Journal of Nutrition; 2007, 97(5):921-927.
53Rocha, A.P., et. al. “Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açaí) extracts in mesenteric vascular bed of the rat.“ Vascular Pharmacology; 2007, 46(2):97-104.
54Matheus ME, et. al. “Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression.“ Journal of Ethnopharmacology; 2006, 107(2):291-296.
55Schauss, A.G., et. al. “Antioxidant capacity and other bioactivities of the freeze-dried Amazonian palm berry, Euterpe oleraceae mart. (acai).“ Journal of Agricultural and Food Chemistry; 2006, 54(22):8604-8610.
56Mertens-Talcott, S.U., et. al. “Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers.“ Journal of Agricultural and Food Chemistry; 2008, 56(17):7796-7802.
57Pizzorno, J. & Murray, M. Textbook of Natural Medicine, 2nd Ed. London: Churchill Livingstone, 1999.
58“Selenium. Monograph.“ Alternative Medicine Review; 2003, 8(1):63-71.
59de Lorgeril, M., Salen, P. “Selenium and antioxidant defenses as major mediators in the development of chronic heart failure.“ Heart Failure Reviews; 2006, 11(1):13-17.
60Rayman, M.P. “Selenium in cancer prevention: a review of the evidence and mechanism of action.“ The Proceedins of the Nutrition Society; 2005, 64(4):527-542.
61Steinbrenner, H., Sies, H. “Protection against reactive oxygen species by selenoproteins.“ Biochimica et Biophysica Acta; 2009, Mar. 5. [Epub ahead of print]
62Zachara, B.A., et. al. “Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review.“ Acta Biochimica Polonica; 2006, 53(4):663-677.
63Venardos, K.M., et. al. “Myocardial ischemia-reperfusion injury, antioxidant enzyme systems, and selenium: a review.“ Current Medical Chemistry; 2007, 14(14):1539-1549.
64Zhou, X., et. al. “Enhancement of endogenous defenses against ROS by supra-nutritional level of selenium is more safe and effective than antioxidant supplementation in reducing hypertensive target organ damage.” Medical Hypotheses; 2007, 68(5):952-956.