Fizz Active-Immune

  • Stock #3045-5 (20 effervescent tablets)
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Fizz Active-Immune contains a powerful blend of herbal extracts and nutrients that have been shown to enhance immune function and increase the body’s resistance to infections, such as the common cold and flu. Each Fizz Active-Immune effervescent tablet quickly dissolves in water to provide rapid absorption of the immune-stimulating ingredients. Each Fizz Active-Immune effervescent tablet contains:

Vitamin C is essential for stimulating the immune system, as research shows that levels of vitamin C in plasma and leukocytes (white blood cells) quickly decrease during infections and as a result of stress, thus reducing the body’s resistance to certain pathogens (disease-causing organisms). Numerous studies have shown that supplementation with vitamin C enhances immune system function, including antimicrobial and natural killer cell activity, as well as the proliferation of lymphocytes (a type of white blood cell). Vitamin C has also been shown to reduce the effects that some allergy-producing substances have on the body. In addition, research indicates that vitamin C inhibits the multiplication of viruses in vitro, including herpes simplex type 1, influenza, and poliovirus type 1. Furthermore, a review of 29 controlled trials found that vitamin C does appear to shorten the duration and reduce the severity of the common cold.1-6

Zinc – The importance of zinc in resistance to infections by bacteria, virus and fungi is crucial because of its pivotal role in the efficient functioning of the entire immune system. Zinc is essential for thymus gland function and the production of thymic hormones that regulate the body’s defense mechanisms. Zinc is also crucial for maintaining cell-mediated immunity, phagocytosis (the process by which white blood cells fight infection), and natural killer (NK) cell activity. Various studies have confirmed the benefits of zinc supplementation on infectious diseases in humans, including the ability to reduce the occurrence of and increase the survival rate following infection in the elderly. In addition, a large number of randomized controlled intervention trials have found that adequate intakes of zinc and vitamin C can reduce the symptoms and shorten the duration of respiratory tract infections, including the common cold.4,6-11

Potassium is an essential mineral required for healthy energy metabolism and cellular functions, as well as for preserving proper alkalinity of body fluids. Potassium also assists with muscle contraction and nervous system activity, regulates fluid and mineral balance, and works in conjunction with sodium to normalize the heartbeat. Supplementation with potassium bicarbonate may help to reduce or reverse bone loss by significantly reducing urine calcium excretion.1,7,12-14

Beta glucans, naturally occurring polysaccharides derived from algae, barley, mushrooms, oats and baker’s yeast (Saccharomyces cerevisiae), have been recognized by researchers for over 40 years for providing immune-modulating activities associated with increased resistance to bacterial, viral and parasitic infections. Beta glucans stimulate the immune system, modulating both humoral and cellular immunity. For example, research shows that beta glucans enhance macrophage (a type of white blood cell) and natural killer (NK) cell activities. Beta glucans also facilitate the transmission of cellular information among the macrophages, T-cells, B-cells, antibodies, and interferons (substances that fights viral infection by inhibiting viral growth) and interleukins (substances that regulate immune system function), thus enhancing overall immune response.15-22

Arabinogalactan, a polysaccharide found in echinacea and in concentrated amounts in the Western larch tree (Larix spp.), is believed to be the constituent primarily responsible for echinacea’s effective immune-stimulating properties. Arabinogalactan enhances natural killer (NK) cell activity and stimulates macrophage production ofinterleukin-1 (an immune system hormone that stimulates T-cell function) and interferon-beta 2 (a substance that fights viral infection). Such effects suggest that arabinogalactan may be beneficial in supporting the body’s natural defenses in the prevention and treatment of colds and influenza. Research also indicates that larch arabinogalactan can reduce the occurrence and severity of otitis media (middle ear infections) in children. In addition, arabinogalactan enhances beneficial microflora in the gastrointestinal tract, as well as the production of butyrate, a substance that is essential for colon health and protects the intestinal mucosa against disease and carcinogens. Furthermore, combining arabinogalactan with antioxidants such as vitamin C may enhance its efficacy.6,23-29

Echinacea (Echinacea purpurea) is notably the most recognized herbal supplement for preventing and treating colds and flu. Echinacea demonstrates antibacterial, antiviral and immunostimulant properties. Echinacea also helps reduce disease-producing waste material in the lymphatic system by stimulating macrophage activity—macrophages filter out and destroy foreign particles, bacteria and toxins in the lymph fluid. Clinical studies support the use of echinacea for preventing and treating colds, flus and upper respiratory infections, as well as increasing general immune system function. For example, a meta-analysis of 14 studies found that echinacea reduced the incidence of the common cold by 58% and the duration of cold symptoms by 1.4 days.6,7,30-34

Elderberry (Sambucus nigra) is primarily used as an antiviral agent to improve immunity against colds and influenza. Studies show that taking elderberry extract at the first sign of a cold or flu can cut recovery time in half. A randomized, double-blind, placebo-controlled study of patients with influenza A and B infections found that elderberry relieved flu-like symptoms an average of 4 days earlier compared to placebo. In addition, the German Commission E has approved elderberry for the treatment of colds and fevers. Elderberry is rich in vitamins A and C, both of which are known to strengthen the immune system, and iron, which is needed by the body to manufacture enzymes and oxidants that destroy bacteria known to cause colds.6,31,35-39

Korean ginseng (Panax ginseng), also known as Asian ginseng, has been shown to improve the immune response, in part, by stimulating the production of white blood cells and interferon (a substance that fights viral infection by inhibiting viral growth) and by enhancing phagocytosis. The active constituents in Korean ginseng include acidic polysaccharides, which demonstrate multiple immunomodulating effects. Animal research has confirmed that treatment with Korean ginseng polysaccharides stimulates humoral and cellular immune factors to increase resistance against infection. Furthermore, a two-year clinical observation of Japanese heart patients found that Korean ginseng significantly reduced the incidence of common cold symptoms and flu, including fever, headache, chills, pain in the joints and/or muscles, nasal discharge, cough and sore throat.40-48

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1Dunne, L.J. Nutrition Almanac, 3rd Ed. NY, NY: McGraw-Hill Publishing Co.; 1990.
2Deruelle, F., Baron, B. “Vitamin C: is supplementation necessary for optimal health?“ Journal of Alternative and Complementary Medicine; 2008, 14(10):1291-1298.
3Ströhle, A., Hahn, A. [Vitamin C and immune function]. Medizinische Monatsschrift für Pharmazeuten; 2009, 32(2):49-54.
4Wintergerst, E.S., et. al. “Immune-enhancing role of vitamin C and zinc and effect on clinical conditions.“ Annals of Nutrition & Metabolism; 2006, 50(2):85-94.
5Furuya, A., et. al. “Antiviral effects of ascorbic and dehydroascorbic acids in vitro.“ International Journal of Molecular Medicine; 2008, 22(4):541-545.
6Roxas, M., Jurenka, J. “Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations.“ Alternative Medicine Review; 2007, 12(1):25-48.
7Pizzorno, J. & Murray, M. Textbook of Natural Medicine, 2nd Ed. London: Churchill Livingstone, 1999.
8Hendler MD, S. The Doctor’s Vitamin & Mineral Encyclopedia. NY, NY: Simon & Schuster, 1990.
9Prasad, A.S. “Zinc in human health: effect of zinc on immune cells.“ Molecular Medicine; 2008, 14(5-6):353-357.
10Overbeck, S., et. al. “Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases.“ Archivum Immunologiae et Therapiae Experimentalis; 2008, 56(1):15-30.
11Mocchegiani, E. & Muzzioli, M. “Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections.” Journal of Nutrition; 2000, 130(5S Suppl):1424S-1431S.
12“FDA Grants Health Claim to Potassium.” Nutrition Science News; January 2001.
13Lieberman PhD, S. & Bruning, N. The Real Vitamin & Mineral Book, 2nd Ed. Avery; 1997.
14Frassetto, L., et. al. “Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.“ The Journal of Clinical Endocrinology and Metabolism; 2005, 90(2):831-834.
15Orey, C. “Immunity Nutrition.” Energy Times; 2000, 10(9):25-29.
16Aviv, S. “Beta glucan for immunity.” Natural Health; 2000, 30(9):38.
17Shokri, H., et. al. “Isolation of beta-glucan from the cell wall of Saccharomyces cerevisiae.“ Natural Product Research; 2008, 22(5):414-421.
18Pelizon, A.C., et. al. “Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae.“ Physiology Research; 2005;54(5):557-564.
19Tsoni, S.V., Brown, G.D. “beta-Glucans and dectin-1.“ Annals of the New York Academy of Sciences; 2008, 1143:45-60.
20Volman, J.J., et. al. “Dietary modulation of immune function by beta-glucans.“ Physiology & Behavior; 2008, 94(2):276-284.
21Mantovani MS, et. al. “beta-Glucans in promoting health: prevention against mutation and cancer.“ Mutation Research; 2008, 658(3):154-161.
22Akramiene, D., et. al. “Effects of beta-glucans on the immune system.“ Medicina(Kaunas, Lithuania); 2007, 43(8):597-606.
23Gregory, C. “Study could put echinacea back on cold-and-flu-season shopping list.” Natural Foods Merchandiser; October, 1999.
24Luettig, B., et. al. “Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea.” Journal of the National Cancer Institute; 1989, 81(9):669-675.
25“Larch: The New Echinacea?” Nutrition Science News; September, 1999.
26Kim, L.S., et. al. “Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial.” Alternative Medicine Review; 2002, 7(2):138-149.
27Kelly, G.S. “Larch arabinogalactan: clinical relevance of a novel immune-enhancing polysaccharide.” Alternative Medicine Review; 1999, 4(2):96-103.
28D’Adamo, P. “Larch Arabinogalactan is a Novel Immune Modulator.“ Journal of Naturopathic Medicine; 1996, (4):32-39.
29“Larch arabinogalactan.“ Alternative Medicine Review; 2000 Oct;5(5):463-466.
30Stansbury ND, J. “A Well-Oiled Machine.” Nutrition Science News; December 2000.
31Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Comm., 2000.
32Presser PharmD, A. Pharmacist’s Guide to Medicinal Herbs. Petaluma, CA: Smart Publications, 2000.
33“Echinacea.” Alternative Medicine Review; 2001, 6(4):411-414.
34Shah, S.A., et. al. “Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.“ The Lancet Infectious Diseases; 2007, 7(7):473-480.
35Lininger DC, S., et al. The Natural Pharmacy, 2nd Ed. Rocklin, CA: Prima Health, 1999.
36“Elderberry: Natural ally against flu.” Nature’s Impact; October/November, 1997.
37Vukovic, L. “Get Ready for the Cold and Flu Season.” Natural Foods Merchandiser; October 2003.
38Zakay-Rones, Z., et. al. “Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.“ The Journal of International Medical Research; 2004 Mar-Apr;32(2):132-140.
39“Monograph. Sambucus nigra (elderberry).“ Alternative Medicine Review; 2005, 10(1):51-54.
40Kiefer, D., Pantuso, T. “Panax ginseng.“ American Family Physician; 2003, 68(8):1539-1542.
41Choi, K.T. “Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer.“ Acta Pharmacologica Sinica; 2008, 29(9):1109-1118.
42Ahn, J.Y., et. al. “Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan.“ FEMS Immunology and Medical Microbiology; 2006, 46(2):187-197.
43—. “The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals.“ European Journal of Immunology; 2006, 36(1):37-45.
44Helms, S. “Cancer prevention and therapeutics: Panax ginseng.“ Alternative Medicine Review; 2004, 9(3):259-274.
45Chang, Y.S., et. al. “Panax ginseng: a role in cancer therapy?” Integrative Cancer Therapies; 2003, 2(1):13-33.
46Song, J.Y., et. al. “Effects of polysaccharide ginsan from Panax ginseng on liver function.” Archives of Pharmacal Research; 2004, 27(5):531-538.
47Smolina, T.P., et. al. [Immunotropic activity of panaxans—bioglycans isolated from ginseng]. Antibiotiki i Khimioterapiia; 2001;46(7):19-22.
48Kaneko, H., Nakanishi, K. “Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease.” Journal of Pharmacological Sciences; 2004, 95(2):158-162.